CD4+ T helper 2 cells--microbial triggers, differentiation requirements and effector functions.
Immunology
; 134(4): 368-77, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-22043920
ABSTRACT
Over the past 10 years we have made great strides in our understanding of T helper cell differentiation, expansion and effector functions. Within the context of T helper type 2 (Th2) cell development, novel innate-like cells with the capacity to secrete large amounts of interleukin-5 (IL-5), IL-13 and IL-9 as well as IL-4-producing and antigen-processing basophils have (re)-emerged onto the type 2 scene. To what extent these new players influence αß+ CD4+ Th2 cell differentiation is discussed throughout this appraisal of the current literature. We highlight the unique features of Th2 cell development, highlighting the three necessary signals, T-cell receptor ligation, co-stimulation and cytokine receptor ligation. Finally, putting these into context, microbial and allergenic properties that trigger Th2 cell differentiation and how these influence Th2 effector function are discussed and questioned.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Diferenciación Celular
/
Células Th2
/
Inmunidad Innata
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Immunology
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido