Nickel-catalyzed C-H/C-O coupling of azoles with phenol derivatives.
J Am Chem Soc
; 134(1): 169-72, 2012 Jan 11.
Article
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| MEDLINE
| ID: mdl-22148419
ABSTRACT
The first nickel-catalyzed C-H bond arylation of azoles with phenol derivatives is described. The new Ni(cod)(2)/dcype catalytic system is active for the coupling of various phenol derivatives such as esters, carbamates, carbonates, sulfamates, triflates, tosylates, and mesylates. With this C-H/C-O biaryl coupling, we synthesized a series of privileged 2-arylazoles, including biologically active alkaloids. Moreover, we demonstrated the utility of the present reaction for functionalizing estrone and quinine.
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MEDLINE
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J Am Chem Soc
Año:
2012
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Article
País de afiliación:
Japón