A new experimental flap design: the saphenous artery periosto-fasciocutaneous flap of the rat.
J Reconstr Microsurg
; 28(3): 175-9, 2012 Mar.
Article
en En
| MEDLINE
| ID: mdl-22274770
ABSTRACT
Vascularized periosteal graft is a frequently applied flap model for bone prefabrication studies due to its inhabitance of osteoprogenitor cells and osteoinductive potential. Various bones such as rib and fibula are reported as a potential source for the harvest of the periosteal flap in experimental studies on higher species such as dogs and pigs, which necessitates a rather complicated and expensive experimental setting. Therefore a reliable and inexpensive small animal model on vascularized periosteal flaps is necessary for future research. A new saphenous artery based periosto-fasciocutaneous flap model in rats is described here, which is easily dissected and monitorized. In this experimental study, 15 male Sprague Dawley rats were operated and killed following a 3-month-long follow-up period . The histological analysis revealed heterotopic osteoneogenesis in 12 of 15 flaps (80%), whereas 14 flaps (93.3%) exhibited signs of angioneogenesis originating from the periostofasciocutaneous flap. The presented flap model promises to be an appropriate alternative for new studies where bone prefabrication methods are evaluated.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Colgajos Quirúrgicos
/
Cicatrización de Heridas
/
Trasplante Óseo
/
Trasplante de Piel
/
Arterias Tibiales
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
J Reconstr Microsurg
Asunto de la revista:
NEUROCIRURGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Turquía