Expression of epidermal growth factor receptor in laryngeal dysplasia and carcinoma.
Acta Otolaryngol
; 110(3-4): 309-13, 1990.
Article
en En
| MEDLINE
| ID: mdl-2239223
ABSTRACT
The immunoreactivity of epidermal growth factor receptor (EGFR) was studied in laryngeal biopsy specimens from 24 patients. The study comprised 5 cases of normal laryngeal mucosa, 5 cases of dysplasia, 7 cases of well differentiated squamous cell carcinoma, and 7 cases of poorly to moderately differentiated squamous cell carcinoma. EGFR was in general not expressed in normal and dysplastic epithelia, whilst all carcinomas showed a rather strong positive immunoreactivity. There was no significant difference in staining patterns between the well and poorly to moderately differentiated carcinomas. The results suggest that EGFR constitutes a component of neoplastic, but probably not preneoplastic, laryngeal disease. The study failed to reveal any difference in staining pattern between different types of laryngeal squamous cell carcinoma.
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Bases de datos:
MEDLINE
Asunto principal:
Carcinoma de Células Escamosas
/
Neoplasias Laríngeas
/
Receptores ErbB
/
Mucosa Laríngea
Límite:
Humans
Idioma:
En
Revista:
Acta Otolaryngol
Año:
1990
Tipo del documento:
Article
País de afiliación:
Japón