Using Tablet for visual exploration of second-generation sequencing data.
Brief Bioinform
; 14(2): 193-202, 2013 Mar.
Article
en En
| MEDLINE
| ID: mdl-22445902
ABSTRACT
The advent of second-generation sequencing (2GS) has provided a range of significant new challenges for the visualization of sequence assemblies. These include the large volume of data being generated, short-read lengths and different data types and data formats associated with the diversity of new sequencing technologies. This article illustrates how Tablet-a high-performance graphical viewer for visualization of 2GS assemblies and read mappings-plays an important role in the analysis of these data. We present Tablet, and through a selection of use cases, demonstrate its value in quality assurance and scientific discovery, through features such as whole-reference coverage overviews, variant highlighting, paired-end read mark-up, GFF3-based feature tracks and protein translations. We discuss the computing and visualization techniques utilized to provide a rich and responsive graphical environment that enables users to view a range of file formats with ease. Tablet installers can be freely downloaded from http//bioinf.hutton.ac.uk/tablet in 32 or 64-bit versions for Windows, OS X, Linux or Solaris. For further details on the Tablet, contact tablet@hutton.ac.uk.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Gráficos por Computador
/
Presentación de Datos
/
Bases de Datos Genéticas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Brief Bioinform
Asunto de la revista:
BIOLOGIA
/
INFORMATICA MEDICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Reino Unido