[Research progress of the selective sphingosine-1-phosphate receptor 1 agonists].
Yao Xue Xue Bao
; 47(1): 7-17, 2012 Jan.
Article
en Zh
| MEDLINE
| ID: mdl-22493799
ABSTRACT
Sphingosine-1-phosphate (S1P) is a lysophospholipid signaling molecule that regulates important biological functions in both intracellular and extracellular compartments. It interacts with five G protein-coupled receptors subtypes (S1PR(1-5)) to generate multiple downstream signaling. Activation of S1PR1 has been validated to be involved in the process of immune modulation. Fingolimod (FTY720), the novel S1PR1 agonist, has been approved for the treatment of multiple sclerosis in clinical trials. The study towards discovery of selective S1PR1 agonists has become hot spot for immunological diseases. This article summarized the research progress of S1PR1 agonists, emphasizing their structure types, structure-activity relationship and direction of development.
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Bases de datos:
MEDLINE
Asunto principal:
Glicoles de Propileno
/
Esfingosina
/
Receptores de Lisoesfingolípidos
/
Inmunosupresores
/
Esclerosis Múltiple
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
2012
Tipo del documento:
Article
País de afiliación:
China