Enantioselective synthesis of dihydropyrazoles by formal [4+1] cycloaddition of in situ-derived azoalkenes and sulfur ylides.
J Am Chem Soc
; 134(16): 6924-7, 2012 Apr 25.
Article
en En
| MEDLINE
| ID: mdl-22497267
ABSTRACT
An unprecedented strategy to access highly enantioenriched dihydropyrazoles is described. It involves formal [4+1] cycloadditions of in situ-derived azoalkenes and sulfur ylides catalyzed by a chiral copper/Tol-BINAP complex. A variety of synthetically and biologically important dihydropyrazoles have been obtained with high enantioselectivities (up to 973 er) in good yields (83-97%).
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Pirazoles
/
Azufre
/
Compuestos Azo
/
Alquenos
Idioma:
En
Revista:
J Am Chem Soc
Año:
2012
Tipo del documento:
Article
País de afiliación:
China