Disease progression model in subjects with mild cognitive impairment from the Alzheimer's disease neuroimaging initiative: CSF biomarkers predict population subtypes.
Br J Clin Pharmacol
; 75(1): 146-61, 2013 Jan.
Article
en En
| MEDLINE
| ID: mdl-22534009
ABSTRACT
AIM:
The objective is to develop a semi-mechanistic disease progression model for mild cognitive impairment (MCI) subjects. The model aims to describe the longitudinal progression of ADAS-cog scores from the Alzheimer's disease neuroimaging initiative trial that had data from 198 MCI subjects with cerebrospinal fluid (CSF) information who were followed for 3 years.METHOD:
Various covariates were tested on disease progression parameters and these variables fell into six categories imaging volumetrics, biochemical, genetic, demographic, cognitive tests and CSF biomarkers.RESULTS:
CSF biomarkers were associated with both baseline disease score and disease progression rate in subjects with MCI. Baseline disease score was also correlated with atrophy measured using hippocampal volume. Progression rate was also predicted by executive functioning as measured by the Trail B-test.CONCLUSION:
CSF biomarkers have the ability to discriminate MCI subjects into sub-populations that exhibit markedly different rates of disease progression on the ADAS-cog scale. These biomarkers can therefore be utilized for designing clinical trials enriched with subjects that carry the underlying disease pathology.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Biomarcadores
/
Disfunción Cognitiva
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Br J Clin Pharmacol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos