Sleep spindles predict neural and behavioral changes in motor sequence consolidation.
Hum Brain Mapp
; 34(11): 2918-28, 2013 Nov.
Article
en En
| MEDLINE
| ID: mdl-22674673
ABSTRACT
The purpose of this study was to investigate the predictive function of sleep spindles in motor sequence consolidation. BOLD responses were acquired in 10 young healthy subjects who were trained on an explicitly known 5-item sequence using their left nondominant hand, scanned at 900 pm while performing that same task and then were retested and scanned 12 h later after a night of sleep during which polysomnographic measures were recorded. An automatic algorithm was used to detect sleep spindles and to quantify their characteristics (i.e., density, amplitude, and duration). Analyses revealed significant positive correlations between gains in performance and the amplitude of spindles. Moreover, significant increases in BOLD signal were observed in several motor-related areas, most of which were localized in the right hemisphere, particularly in the right cortico-striatal system. Such increases in BOLD signal also correlated positively with the amplitude of spindles at several derivations. Taken together, our results show that sleep spindles predict neural and behavioral changes in overnight motor sequence consolidation.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Desempeño Psicomotor
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Sueño
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Fases del Sueño
/
Destreza Motora
Tipo de estudio:
Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Hum Brain Mapp
Asunto de la revista:
CEREBRO
Año:
2013
Tipo del documento:
Article
País de afiliación:
Canadá