Serum IL-23 strongly and inversely correlates with FEV1 in asthmatic children.
Int Arch Allergy Immunol
; 159(2): 183-6, 2012.
Article
en En
| MEDLINE
| ID: mdl-22678234
ABSTRACT
BACKGROUND:
Recently, Th17 cells have been found to participate in the pathogenesis of allergic asthma. IL-23 is a cytokine that may be implicated in modulating Th17 response. This study aimed at evaluating IL-23 and relating it to lung function in asthmatic children.METHODS:
Seventy-eight asthmatic children and 40 healthy children were evaluated. Spirometry and serum IL-23 measurement (ELISA kit) were performed in all asthmatic children.RESULTS:
IL-23 levels were higher in asthmatic than in healthy children (p < 0.001). There was a strong inverse relationship between FEV(1) and IL-23 (r = -0.787).CONCLUSIONS:
This preliminary study suggests that serum IL-23 could be a suitable marker of bronchial function impairment in allergic asthmatic children.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Asma
/
Interleucina-23
Tipo de estudio:
Observational_studies
Límite:
Adolescent
/
Child
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Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Int Arch Allergy Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Italia