An effectiveness trial showed lipid-based nutrient supplementation but not corn-soya blend offered a modest benefit in weight gain among 6- to 18-month-old underweight children in rural Malawi.
Public Health Nutr
; 15(9): 1755-62, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-22691922
ABSTRACT
OBJECTIVE:
To determine if supplementation with corn-soya blend (CSB) or lipid-based nutrient supplement (LNS) improved the weight gain of moderately underweight infants and children when provided through the national health service.DESIGN:
A randomised, controlled, assessor-blinded clinical trial. Infants and children were randomised to receive for 12 weeks an average daily ration of 71 g CSB or 43 g LNS, providing 1188 kJ and 920 kJ, respectively, or no supplement (control). Main outcome was weight gain. Secondary outcomes included changes in anthropometric indices and incidence of serious adverse events. Intention-to-treat analyses were used.SETTING:
Kukalanga, Koche, Katema and Jalasi health centres in Mangochi District, rural Malawi.SUBJECTS:
Underweight (weight-for-age Z-score <-2) infants and children aged 6-15 months (n 299).RESULTS:
Mean weight gain was 630 g, 680 g and 750 g in control, CSB and LNS groups, respectively (P = 0·21). When adjusted for baseline age, children receiving LNS gained on average 90 g more weight (P = 0·185) and their weight-for-length Z-score increased 0·22 more (P = 0·049) compared with those receiving no supplementation. No statistically significant differences were observed between the CSB and control groups in mean weight and length gain.CONCLUSIONS:
LNS supplementation provided during the lean season via through the national health service was associated with a modest increase in weight. However, the effect size was lower than that previously reported under more controlled research settings.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Población Rural
/
Delgadez
/
Suplementos Dietéticos
/
Fenómenos Fisiológicos Nutricionales del Lactante
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
/
Infant
País/Región como asunto:
Africa
Idioma:
En
Revista:
Public Health Nutr
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
SAUDE PUBLICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Malawi