Levetiracetam-induced reversible autistic regression.
Pediatr Neurol
; 47(1): 65-7, 2012 Jul.
Article
en En
| MEDLINE
| ID: mdl-22704022
ABSTRACT
Levetiracetam is a commonly prescribed antiepileptic drug, and is generally well tolerated, but can eventually cause behavioral disturbances. These disturbances seem more frequent in children and in patients with a previous psychiatric history. We report on reversible autistic regression induced by levetiracetam in a 6-year-old girl with spastic cerebral palsy, mild cognitive deficiency, and focal epilepsy. She was diagnosed with pervasive developmental disorder, and demonstrated mild to moderate impairment in pragmatic language and interactions with peers. After the introduction of levetiracetam, she developed stereotypies, and her social and communicative skills deteriorated severely. She also exhibited mood lability. When the medication was discontinued, a dramatic response occurred, with a complete resolution of new abnormal findings. Levetiracetam can provoke unusual behavioral adverse effects in certain patients who are biologically more vulnerable.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Piracetam
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Regresión Psicológica
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Trastorno Autístico
/
Anticonvulsivantes
Tipo de estudio:
Etiology_studies
Límite:
Child
/
Female
/
Humans
Idioma:
En
Revista:
Pediatr Neurol
Asunto de la revista:
NEUROLOGIA
/
PEDIATRIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
España