Lung cancer in patients with lung transplants.
Transplant Proc
; 44(7): 2118-9, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-22974929
ABSTRACT
OBJECTIVE:
The aim of our study was to describe the incidence of lung cancer in patients after lung transplantation (LT). MATERIALS ANDMETHODS:
We performed an observational, retrospective, descriptive study based on data from 340 patients undergoing lung transplantation between October 1993 and December 2010. We collected data about the donors, recipients, intra- and postoperative periods, and survivals.RESULTS:
We identified 9 (2.6%) patients who developed lung cancer after LT. Their average age was 56 ± 9.3 years (range, 18-63). All cases were men with 8/9 (88.8%) having received a single lung transplant. All cancers developed in the native lung. The indications for transplantation were emphysema type chronic obstructive pulmonary disease (COPD; n = 5), idiopathic pulmonary fibrosis (n = 3), or cystic fibrosis (n = 1); 77% of them were former smokers. All of the COPD patient were affected. The interval from transplantation to diagnosis was 53.3 ± 12 months (range 24-86). Survival after cancer diagnosis was 49.3 ± 6.3 (range = 0-180) months.CONCLUSIONS:
LT was associated with a relatively high incidence of lung cancer, particularly in the native lung. In our series, lung cancer was related more to patients with emphysema-type COPD and a history of smoking. We believe that these patients should be closely followed to establish the diagnosis and apply early treatment.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Trasplante de Pulmón
/
Neoplasias Pulmonares
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Transplant Proc
Año:
2012
Tipo del documento:
Article
País de afiliación:
España