Identification of upregulated genes in oral squamous cell carcinomas.
Head Neck
; 35(10): 1475-81, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-22987617
ABSTRACT
BACKGROUND:
Oral cancer is the most common subset of head and neck squamous cell carcinomas (HNSCC). These tumors often have an aggressive clinical outcome hallmarked by a propensity for local invasion and regional nodal metastasis. Upregulated genes could be useful as markers for diagnosis, prognosis, and as new drug targets for these tumors.METHODS:
To identify upregulated genes in oral squamous cell carcinomas (OSSCs), we examined the ORESTES public database and used a quantitative reverse transcription-polymerase chain reaction (qRT-PCR) approach to determine the expression level of selected genes in tumor samples. RESULTS ANDCONCLUSIONS:
The ORESTES data mining analysis indicated 40 upregulated genes in HNSCC. Nine of these candidate genes were selected for further qRT-PCR validation and 3 of them (ALDOA, AHSA1, and POLQ) were frequently found upregulated in OSCC samples, which may indicate an association of these genes with the carcinogenesis process in this tumor site and they can constitute potential new targets for therapy.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
ARN Neoplásico
/
Neoplasias de la Boca
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Carcinoma de Células Escamosas
/
Regulación Neoplásica de la Expresión Génica
/
Neoplasias de Cabeza y Cuello
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Head Neck
Asunto de la revista:
NEOPLASIAS
Año:
2013
Tipo del documento:
Article
País de afiliación:
Brasil