Scope of the two-step, one-pot palladium-catalyzed borylation/Suzuki cross-coupling reaction utilizing bis-boronic acid.
J Org Chem
; 77(19): 8678-88, 2012 Oct 05.
Article
en En
| MEDLINE
| ID: mdl-22994557
The use of bis-boronic acid for the direct synthesis of boronic acids has greatly facilitated the two-step, one-pot borylation/Suzuki cross-coupling reaction between aryl and heteroaryl halides. With use of Buchwald's second-generation XPhos preformed catalyst, high yields of cross-coupled products were obtained for most substrates. The method also allows an efficient two-step, one-pot synthesis, providing access to three distinct cross-coupled products after column chromatography. The method also provides a rapid and convenient route to teraryl compounds.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Paladio
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Ácidos Borónicos
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Reactivos de Enlaces Cruzados
/
Hidrocarburos Halogenados
Idioma:
En
Revista:
J Org Chem
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos