Testing for the recurrent HOXB13 G84E germline mutation in men with clinical indications for prostate biopsy.
J Urol
; 189(3): 849-53, 2013 Mar.
Article
en En
| MEDLINE
| ID: mdl-23036981
ABSTRACT
PURPOSE:
The G84E variant of HOXB13 was recently found to be associated with a significantly increased risk of prostate cancer in a case control study. We estimated the prevalence of this mutation in a clinical population of men at risk for prostate cancer who were scheduled to undergo prostate biopsy. MATERIALS ANDMETHODS:
We prospectively collected clinical information and DNA samples from men who underwent diagnostic prostate biopsy between June 2005 and October 2011. We genotyped samples for HOXB13 G84E using the MassARRAY® system. We determined the prevalence of the G84E variant in the overall cohort, among patients with a positive family history and among men age 55 years or younger.RESULTS:
A total of 1,175 subjects underwent biopsy, of whom 948 had a DNA sample for analysis. The G84E variant was detected in 4 patients (prevalence 0.42%, 95% CI 0.12-1.08), of whom 3 had prostate cancer on biopsy. None of 301 patients with a positive family history (prevalence 0.00%, 95% CI 0.00-1.22) and 1 of 226 patients age 55 years or younger tested positive (prevalence 0.44%, 95% CI 0.01-2.44).CONCLUSIONS:
The HOXB13 G84E variant is rare in this cohort, even among those with a positive family history. Our findings question the utility of testing for this variant among unselected men presenting for a diagnostic prostate biopsy.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Próstata
/
Neoplasias de la Próstata
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Biopsia
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ADN de Neoplasias
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Mutación de Línea Germinal
/
Proteínas de Homeodominio
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Urol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos