Association study of FUT2 (rs601338) with celiac disease and inflammatory bowel disease in the Finnish population.
Tissue Antigens
; 80(6): 488-93, 2012 Dec.
Article
en En
| MEDLINE
| ID: mdl-23075394
ABSTRACT
Homozygosity for a nonsense mutation in the fucosyltransferase 2 (FUT2) gene (rs601338G>A) leads to the absence of ABH blood groups (FUT2 non-secretor status) in body fluids. As the secretor status has been shown to be a major determinant for the gut microbial spectrum, assumed to be important in the gut immune homeostasis, we studied the association of rs601338-FUT2 with celiac disease (CelD) and inflammatory bowel disease (IBD) in the Finnish population. Rs601338 was genotyped in CelD (n = 909), dermatitis herpetiformis (DH) (n = 116), ulcerative colitis (UC) (n = 496) and Crohn's disease (CD) (n = 280) patients and healthy controls (n = 2738). CelD showed significant genotypic [P = 0.0074, odds ratio (OR) 1.28] and recessive (P = 0.015, OR 1.28) association with the rs601338-AA genotype. This was also found in the combined CelD+DH dataset (genotype association P = 0.0060, OR 1.28; recessive association P < 0.011, OR 1.28). The A allele of rs601338 showed nominal association with dominant protection from UC (P = 0.044, OR 0.82) and UC+CD (P = 0.035, OR 0.84). The frequency of non-secretors (rs601338-GG) in controls, CelD, DH, UC and CD datasets was 14.7%, 18%, 18.1%, 14.3% and 16.1%, respectively. No association was evident in the DH or CD datasets alone. In conclusion, FUT2 non-secretor status is associated with CelD susceptibility and FUT2 secretor status may also play a role in IBD in the Finnish population.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedades Inflamatorias del Intestino
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Enfermedad Celíaca
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Fucosiltransferasas
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Tissue Antigens
Año:
2012
Tipo del documento:
Article
País de afiliación:
Finlandia