Disrupting the luxS quorum sensing gene does not significantly affect Bacillus anthracis virulence in mice or guinea pigs.
Virulence
; 3(6): 504-9, 2012 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-23076278
ABSTRACT
Many bacterial species use secreted quorum-sensing autoinducer molecules to regulate cell density- and growth phase-dependent gene expression, including virulence factor production, as sufficient environmental autoinducer concentrations are achieved. Bacillus anthracis, the causative agent of anthrax, contains a functional autoinducer (AI-2) system, which appears to regulate virulence gene expression. To determine if the AI-2 system is necessary for disease, we constructed a LuxS AI-2 synthase-deficient mutant in the virulent Ames strain of B. anthracis. We found that growth of the LuxS-deficient mutant was inhibited and sporulation was delayed when compared with the parental strain. However, spores of the Ames luxS mutant remained fully virulent in both mice and guinea pigs.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Liasas de Carbono-Azufre
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Bacillus anthracis
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Proteínas Bacterianas
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Percepción de Quorum
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Homoserina
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Lactonas
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Carbunco
Límite:
Animals
Idioma:
En
Revista:
Virulence
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos