HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene.
Science
; 247(4946): 1082-4, 1990 Mar 02.
Article
en En
| MEDLINE
| ID: mdl-2309119
ABSTRACT
Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax down-regulated the expression of human beta-polymerase (hu beta-pol), a cellular enzyme involved in host cell DNA repair. This finding suggests a possible correlation between HTLV-I infection and host chromosomal damage, which is often seen in ATL cells.
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Bases de datos:
MEDLINE
Asunto principal:
Proteínas Represoras
/
Factores de Transcripción
/
Virus Linfotrópico T Tipo 1 Humano
/
Transactivadores
/
ADN Polimerasa I
Límite:
Humans
Idioma:
En
Revista:
Science
Año:
1990
Tipo del documento:
Article