Non-benzimidazole containing inhibitors of respiratory syncytial virus.

Pryde, David C; Tran, Thien-Duc; Gardner, Iain; Bright, Helen; Stupple, Paul; Galan, Sebastien; Alsop, Liam; Watson, Lesa; Middleton, Donald S; Dayal, Satish; Platts, Michelle; Murray, Edward J; Parkinson, Tanya; Webster, Robert

Pryde, David C; Tran, Thien-Duc; Gardner, Iain; Bright, Helen; Stupple, Paul; Galan, Sebastien; Alsop, Liam; Watson, Lesa; Middleton, Donald S; Dayal, Satish; Platts, Michelle; Murray, Edward J; Parkinson, Tanya; Webster, Robert.

Afiliación

Pryde DC; Worldwide Medicinal Chemistry, Pfizer Global R and D, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. David.Pryde@pfizer.com

Bioorg Med Chem Lett ; 23(3): 827-33, 2013 Feb 01.

Article en En | MEDLINE | ID: mdl-23265891

RESUMEN

Several non-benzimidazole containing inhibitors of respiratory syncytial virus are described. Core template modification, analysis of antiviral activity, physicochemistry and optimisation of properties led to the thiazole-imidazole 13, that showed a good potency and pharmacokinetic profile in the rat.

Asunto(s)

Antivirales/síntesis química; Antivirales/farmacología; Virus Sincitiales Respiratorios/efectos de los fármacos; Animales; Antivirales/química; Bencimidazoles/química; Imidazoles/síntesis química; Imidazoles/farmacocinética; Imidazoles/farmacología; Concentración 50 Inhibidora; Ratas; Relación Estructura-Actividad; Tiazoles/síntesis química; Tiazoles/farmacocinética; Tiazoles/farmacología

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antivirales / Virus Sincitiales Respiratorios Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2013 Tipo del documento: Article

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