Relationship between angiogenesis and lymphangiogenesis in recurrent pterygium.
Int J Ophthalmol
; 5(6): 655-60, 2012.
Article
en En
| MEDLINE
| ID: mdl-23275896
ABSTRACT
AIM:
To examine the relationship between angiogenesis and lymphangigenesis in recurrent pterygia.METHODS:
Tissues from 34 excised recurrent pterygia (including 12 Grade 1, 10 Grade 2, and 12 Grade 3) were involved in the study and tissues from 7 nasal epibulbar conjunctivae segments were used as controls. Sections from each pterygium were immunostained with CD(31) and LYVE-1 monoclonal antibodies to evaluate lymphatic microvessel density (LMVD) and blood microvessel density (BMVD), and the relationship between LMVD and BMVD in the pterygium was examined.RESULTS:
There was a large number of CD(31) ((+))LYVE-1((-)) blood vessels but only a few CD(31) ((+))LYVE-1((+)) lymphatic vessels in grades 1 and 2 pterygium. However, lymphatic vessels were dramatically increased in grade 3 pterygium. LMVD correlated closely with BMVD in all pterygia, including grades 1, 2 and 3 peterygium patients (all P values <0.01). Although both the density of blood and lymphatic vessels increased in recurrent pterygia, lymphatic vessels developed much faster than blood vessels, especially in grade 3 pterygia.CONCLUSION:
There is a significant but not parallel relationship between angiogenesis and lymphangiogenesis in recurrent pterygium. The outgrowth of blood and lymphatic vessels provide evidence that immunological mechanism may play a role in the development and recurrence of pterygium.
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Bases de datos:
MEDLINE
Idioma:
En
Revista:
Int J Ophthalmol
Año:
2012
Tipo del documento:
Article
País de afiliación:
China