Synthesis and biological activity against Trypanosoma cruzi of substituted 1,4-naphthoquinones.
Eur J Med Chem
; 60: 51-6, 2013 Feb.
Article
en En
| MEDLINE
| ID: mdl-23279867
ABSTRACT
The discovery and development of essential drugs for Chagas disease is a major concern worldwide. New substituted 1,4-naphthoquinones were synthesized and tested against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease. These products exhibited substantial activity against T. cruzi, especially 2-((8E,11Z)-heptadeca-8,11-dienyl)-3-hydroxynaphthalene-1,4-dione (9) with IC(50) of 7.8 µM.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Trypanosoma cruzi
/
Naftoquinonas
/
Antiprotozoarios
Idioma:
En
Revista:
Eur J Med Chem
Año:
2013
Tipo del documento:
Article
País de afiliación:
Brasil