Non-alcoholic steatohepatitis occurs in celiac disease and is associated with cellular stress.
Z Gastroenterol
; 51(1): 26-31, 2013 Jan.
Article
en En
| MEDLINE
| ID: mdl-23315648
ABSTRACT
BACKGROUND AND AIMS:
Liver and gut not only share alimentary but also immunological features. Major histocompatibility complex class I-related chains A and B (MIC A/B) function as indicators for cellular stress. These so called stress-induced ligands are suggested to play an important role in the progression of non-alcoholic fatty liver disease (NAFLD) and are a prominent feature of celiac disease (CD). PATIENTS ANDMETHODS:
In the present study, 24 patients with celiac disease and 20 patients with non-alcoholic steatohepatitis (NASH) were included. Liver enzymes, serum cell death markers (M30, M65), MIC B and expression of adiponectin were determined.RESULTS:
Mean patient age was 42 years (18 - 69) for CD and 49 years (33 - 68) for the NASH group.âALT and AST values were lower in CD compared to NASH patients. While serum cell death markers were higher in NASH, the predominant type of cell death in CD was apoptosis. Also, expression of MIC B was significantly up-regulated in CD patients as compared to NASH patients. Adiponectin values were significantly lower in NASH compared to CD patients.CONCLUSION:
Stress-induced ligands and apoptosis are induced in CD. Prospective studies need to determine the exact role of cellular stress and apoptosis in the gut-liver axis and the clinical implications to screen for NAFLD in CD patients.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedad Celíaca
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Estrés Oxidativo
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Adiponectina
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Hígado Graso
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Factores Inmunológicos
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Z Gastroenterol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Alemania