mTOR in aging, metabolism, and cancer.
Curr Opin Genet Dev
; 23(1): 53-62, 2013 Feb.
Article
en En
| MEDLINE
| ID: mdl-23317514
ABSTRACT
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase that is part of two structurally and functionally distinct complexes, TORC1 and TORC2. In multicellular organisms, TOR regulates cell growth and metabolism in response to nutrients, growth factors and cellular energy. Deregulation of TOR signaling alters whole body metabolism and causes age-related disease. This review describes the most recent advances in TOR signaling with a particular focus on mammalian TOR (mTOR) in metabolic tissues vis-a-vis aging, obesity, type 2 diabetes, and cancer.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Serina-Treonina Quinasas TOR
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Genet Dev
Asunto de la revista:
GENETICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Suiza