Skin equivalents: a tool for the discovery and validation of pharmacodynamic biomarkers.
Cancer Invest
; 31(1): 60-6, 2013 Jan.
Article
en En
| MEDLINE
| ID: mdl-23327193
ABSTRACT
In the development of targeted oncology drugs, it is important to assess drug effectiveness in individual patients. We evaluated the possibility of reproducing in an ex-vivo system the biological effects observed in vitro and in vivo by the combined administration of two chemotherapeutic drugs, gemcitabine and a small inhibitor of Wee1. We found that modulation of both CDC2 phosphorylation and of a previously-identified gene signature was detectable in human skin equivalents obtained with primary keratinocytes from three individuals. Therefore, we suggest that human skin equivalents could represent a promising tool for the identification and validation of novel pharmacodynamic biomarkers.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Piel
/
Ensayos de Selección de Medicamentos Antitumorales
/
Biomarcadores
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Invest
Año:
2013
Tipo del documento:
Article
País de afiliación:
Italia