Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes.

Valiahdi, Seied Mojtaba; Egger, Alexander E; Miklos, Walter; Jungwirth, Ute; Meelich, Kristof; Nock, Petra; Berger, Walter; Hartinger, Christian G; Galanski, Mathea Sophia; Jakupec, Michael A; Keppler, Bernhard K

Valiahdi, Seied Mojtaba; Egger, Alexander E; Miklos, Walter; Jungwirth, Ute; Meelich, Kristof; Nock, Petra; Berger, Walter; Hartinger, Christian G; Galanski, Mathea Sophia; Jakupec, Michael A; Keppler, Bernhard K.

Afiliación

Valiahdi SM; Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, 1090, Vienna, Austria.
Egger AE; Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, 1090, Vienna, Austria.
Miklos W; Institute of Cancer Research, Department of Medicine I and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria.
Jungwirth U; Research Platform "Translational Cancer Therapy Research", Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria.
Meelich K; Institute of Cancer Research, Department of Medicine I and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria.
Nock P; Research Platform "Translational Cancer Therapy Research", Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria.
Berger W; Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, 1090, Vienna, Austria.
Hartinger CG; Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, 1090, Vienna, Austria.
Galanski MS; Institute of Cancer Research, Department of Medicine I and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria.
Jakupec MA; Research Platform "Translational Cancer Therapy Research", Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria.
Keppler BK; Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, 1090, Vienna, Austria.

J Biol Inorg Chem ; 18(2): 249-260, 2013 02.

Article en En | MEDLINE | ID: mdl-23354303

Asunto(s)

Antineoplásicos/farmacología; Supervivencia Celular/efectos de los fármacos; Cisplatino/análogos & derivados; Cisplatino/farmacología; Antineoplásicos/química; Apoptosis/efectos de los fármacos; Ciclo Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Cisplatino/química; Complejos de Coordinación/química; Complejos de Coordinación/farmacología; Ciclinas/metabolismo; ADN Circular/química; ADN Superhelicoidal/química; Estabilidad de Medicamentos; Guanosina Monofosfato/química; Células HT29; Humanos; Concentración de Iones de Hidrógeno; Concentración 50 Inhibidora; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Plásmidos/química; Poli(ADP-Ribosa) Polimerasa-1; Poli(ADP-Ribosa) Polimerasas/metabolismo; Proteína p53 Supresora de Tumor/metabolismo

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Supervivencia Celular / Cisplatino / Antineoplásicos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Biol Inorg Chem Asunto de la revista: BIOQUIMICA Año: 2013 Tipo del documento: Article País de afiliación: Austria

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