The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis.
Pancreatology
; 13(1): 29-32, 2013.
Article
en En
| MEDLINE
| ID: mdl-23395566
ABSTRACT
BACKGROUND/AIMS:
The variable number of tandem repeats (VNTR) in the last exon of the carboxyl-ester lipase (CEL) gene has been reported to associate with alcohol-induced chronic pancreatitis (ACP) in a Japanese study. Here, we have investigated the association between the number of CEL VNTR repeats and ACP or idiopathic chronic pancreatitis (ICP) in a cohort of German patients.METHODS:
Patients diagnosed with ACP (n = 203) or ICP (n = 64) were genotyped using a screening method consisting of PCR followed by DNA fragment analysis. The allele frequencies of different CEL VNTR lengths were compared to the frequencies in healthy controls (n = 390).RESULTS:
We observed no statistical significant associations between CEL VNTR allele frequencies and ACP or ICP.CONCLUSION:
This study did not find evidence that supported an association between the common length variations of the CEL VNTR and chronic pancreatitis.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Alcoholismo
/
Pancreatitis Crónica
/
Lipasa
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Pancreatology
Asunto de la revista:
ENDOCRINOLOGIA
/
GASTROENTEROLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Noruega