Structural analogs of huperzine A improve survival in guinea pigs exposed to soman.
Bioorg Med Chem Lett
; 23(5): 1544-7, 2013 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-23395652
Chemical warfare nerve agents such as soman exert their toxic effects through an irreversible inhibition of acetylcholinesterase (AChE) and subsequently glutamatergic function, leading to uncontrolled seizures. The natural alkaloid (-)-huperzine A is a potent inhibitor of AChE and has been demonstrated to exert neuroprotection at an appropriate dose. It is hypothesized that analogs of both (+)- and (-)-huperzine A with an improved ability to interact with NMDA receptors together with reduced AChE inhibition will exhibit more effective neuroprotection against nerve agents. In this manuscript, the tested huperzine A analogs 2 and 3 were demonstrated to improve survival of guinea pigs exposed to soman at either 1.2 or 2×LD(50).
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Sesquiterpenos
/
Inhibidores de la Colinesterasa
/
Fármacos Neuroprotectores
/
Alcaloides
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos