Consumption of coffee associated with reduced risk of liver cancer: a meta-analysis.
BMC Gastroenterol
; 13: 34, 2013 Feb 25.
Article
en En
| MEDLINE
| ID: mdl-23433483
ABSTRACT
BACKGROUND:
Epidemiologic studies have reported inconsistent results regarding coffee consumption and the risk of liver cancer. We performed a meta-analysis of published case-control and cohort studies to investigate the association between coffee consumption and liver cancer.METHODS:
We searched Medline, EMBASE, ISI Web of Science and the Cochrane library for studies published up to May 2012. We performed a meta-analysis of nine case-control studies and seven cohort studies.RESULTS:
The summary odds ratio (OR) for high vs no/almost never drinkers was 0.50 (95% confidence interval (CI) 0.42-0.59), with no significant heterogeneity across studies (Q = 16.71; P = 0.337; I2 = 10.2%). The ORs were 0.50 (95% CI 0.40-0.63) for case-control studies and 0.48 (95% CI 0.38-0.62) for cohort studies. The OR was 0.38 (95% CI 0.25-0.56) in males and 0.60 (95% CI 0.33-1.10) in females. The OR was 0.45 (95% CI 0.36-0.56) in Asian studies and 0.57 (95% CI 0.44-0.75) in European studies. The OR was 0.39 (95% CI 0.28-0.54) with no adjustment for a history of liver disease and 0.54 (95% CI 0.46-0.66) after adjustment for a history of liver disease.CONCLUSIONS:
The results of this meta-analysis suggested an inverse association between coffee consumption and liver cancer. Because of the small number of studies, further prospective studies are needed.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Café
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Conducta de Ingestión de Líquido
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Neoplasias Hepáticas
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
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Systematic_reviews
Límite:
Female
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Humans
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Male
Idioma:
En
Revista:
BMC Gastroenterol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
China