Effects of chronic stress and alendronate therapy on the osseointegration of titanium implants.
Clin Implant Dent Relat Res
; 16(5): 762-71, 2014 Oct.
Article
en En
| MEDLINE
| ID: mdl-23448531
ABSTRACT
PURPOSES:
The purposes of this study were to evaluate the influence of chronic stress (CS) on implant osseointegration and also to analyze whether alendronate (ALN) therapy could prevent these eventual stress-negative effects. MATERIALS ANDMETHODS:
Adult male Holtzmann rats were assigned to one of the four experimental groups AL (ALN; 1 mg/kg/week; n = 12), ALS (ALN + CS; 1 mg/kg/week; n = 12), CTL (sterile physiological saline; n = 12), or CTLS (sterile physiological saline + CS; n = 12). After 58 days of drug therapy, the ALS and CTLS groups were exposed to CS, and 2 days later all animals underwent tibial implant installation. The animals were euthanized 28 days following the operative surgical procedure.RESULTS:
It was observed that the CTLS group presented an impairment of bone metabolism represented by lowest levels of bone-specific alkaline phosphatase and bone area fraction occupancy values. Furthermore, these animals presented a higher proportion of empty osteocytic lacunae. In contrast, the ALN therapy showed increased osseointegration and torque value parameters, regardless of stress exposition.CONCLUSIONS:
Analysis of the data presented suggests that CS partially impairs the osseointegration of tibial implants and that ALN therapy is able to prevent these negative effects.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Estrés Psicológico
/
Titanio
/
Implantes Dentales
/
Oseointegración
Límite:
Animals
Idioma:
En
Revista:
Clin Implant Dent Relat Res
Asunto de la revista:
ODONTOLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Brasil