Intensity-modulated radiotherapy to the pelvis and androgen deprivation in men with locally advanced prostate cancer: a study of adverse effects and their relation to quality of life.
Prostate
; 73(10): 1038-47, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23532709
ABSTRACT
BACKGROUND:
To study, adverse effects, quality of life (QoL), fatigue, and mental distress when intensity-modulated radiotherapy combined with androgen deprivation was applied to the whole pelvis as management of men with locally advanced prostate cancer.METHODS:
In this prospective follow-up study 91 patients were treated by modern pelvic intensity-modulated radiotherapy and followed for 12 months. The patients completed a questionnaire with well-established instruments for adverse effects on urinary, bowel, and sexual function and bother, QoL, fatigue, and mental distress before treatment, and at 3 and 12 months follow-up.RESULTS:
After pelvic intensity-modulated radiotherapy the mean levels of sexual urinary and bowel function and bother were significantly reduced from baseline. Only urinary bother improved from 3 to 12-month follow-up. The levels of fatigue and QoL increased significantly from baseline to 3-month. Mental distress, fatigue, and QoL were significantly associated with both urinary and bowel function and bother at most time points, while so was not observed for sexual bother and function.CONCLUSIONS:
Men treated with pelvic intensity-modulated radiotherapy and androgen deprivation have significant reductions of all types of function and bother at 3 months, with minimal improvement to 12 months except for urinary bother. Fatigue possibly due to pelvic intensity-modulated radiotherapy increased at follow-ups.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Pelvis
/
Neoplasias de la Próstata
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Calidad de Vida
/
Goserelina
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Antineoplásicos Hormonales
/
Radioterapia de Intensidad Modulada
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Prostate
Año:
2013
Tipo del documento:
Article
País de afiliación:
Noruega