Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 influenza virus hemagglutinin.
J Virol
; 87(12): 7149-54, 2013 Jun.
Article
en En
| MEDLINE
| ID: mdl-23552413
ABSTRACT
We report the structural characterization of the first antibody identified to cross-neutralize multiple subtypes of influenza A viruses. The crystal structure of mouse antibody C179 bound to the pandemic 1957 H2N2 hemagglutinin (HA) reveals that it targets an epitope on the HA stem similar to those targeted by the recently identified human broadly neutralizing antibodies. C179 also inhibits the low-pH conformational change of the HA but uses a different angle of approach and both heavy and light chains.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Virus de la Influenza A
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Glicoproteínas Hemaglutininas del Virus de la Influenza
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Subtipo H2N2 del Virus de la Influenza A
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Anticuerpos Neutralizantes
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Anticuerpos Monoclonales
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Anticuerpos Antivirales
Límite:
Animals
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Humans
Idioma:
En
Revista:
J Virol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos