[Simplified, low-cost gene expression profiling for the prediction of outcome in breast cancer based on routine histologic specimens]. / Egyszerusített, alacsony költségu génexpressziós teszt az emlodaganatos betegségek kimenetelének elorejelzésére rutin patológiai blokkok felhasználásával.
Orv Hetil
; 154(16): 627-32, 2013 Apr 21.
Article
en Hu
| MEDLINE
| ID: mdl-23587542
ABSTRACT
BACKGROUND:
Grade 2 breast carcinomas do not form a uniform prognostic group.AIM:
To extend the number of patients and the investigated genes of a previously identified prognostic signature described by the authors that reflect chromosomal instability in order to refine characterization of grade 2 breast cancers and identify driver genes.METHODS:
Using publicly available databases, the authors selected 9 target and 3 housekeeping genes that are capable to divide grade 2 breast carcinomas into prognostic groups. Gene expression was investigated by polymerase chain reaction in 249 formalin-fixed, paraffin-embedded breast tumors. The results were correlated with relapse-free survival.RESULTS:
Histologically grade 2 carcinomas were split into good and a poor prognosis groups. Centroid-based ranking showed that 3 genes, FOXM1, TOP2A and CLDN4 were able to separate the good and poor prognostic groups of grade 2 breast carcinomas.CONCLUSION:
Using appropriately selected control genes, a limited set of genes is able to split prognostic groups of breast carcinomas independently from their grade.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Perfilación de la Expresión Génica
Tipo de estudio:
Health_economic_evaluation
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
Idioma:
Hu
Revista:
Orv Hetil
Año:
2013
Tipo del documento:
Article