Value of D-dimer and protein S for diagnosis of portal vein thrombosis in patients with liver cirrhosis.
J Int Med Res
; 41(3): 664-72, 2013 Jun.
Article
en En
| MEDLINE
| ID: mdl-23637275
ABSTRACT
OBJECTIVE:
To investigate the value of D-dimer and protein S plasma concentrations for diagnosis of portal vein thrombosis (PVT) in patients with liver cirrhosis.METHODS:
D-dimer and protein S were quantified, PVT was diagnosed by dynamic enhanced computed tomography and liver function was classified using the Child-Pugh system. Receiver operating curve analysis was performed.RESULTS:
D-dimer increased, and protein S decreased, with decreasing liver function in the total study population (n = 188). D-dimer concentrations were significantly higher and protein S concentrations were significantly lower in patients with (n = 51) than those without PVT (n = 137). D-dimer had high specificity and negative predictive value (NPV) in Child-Pugh class A or B patients (cut-off values>0.56 mg/l and >1.18 mg/l, respectively). In class C patients>0.77 mg/l D-dimer had high sensitivity and NPV. Protein S had high sensitivity but low specificity in class A or B patients (cut-off values < 17.4 mg/l and <19.2 mg/l, respectively).CONCLUSION:
Plasma D-dimer and protein S are potential biomarkers for PVT diagnosis in patients with cirrhosis. PVT can be excluded when D-dimer is low and protein S is elevated.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Vena Porta
/
Productos de Degradación de Fibrina-Fibrinógeno
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Proteína S
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Trombosis de la Vena
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Hígado
/
Cirrosis Hepática
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adult
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Aged
/
Aged80
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Int Med Res
Año:
2013
Tipo del documento:
Article
País de afiliación:
China