The role of intracellular calcium stores in synaptic plasticity and memory consolidation.
Neurosci Biobehav Rev
; 37(7): 1211-39, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23639769
ABSTRACT
Memory processing requires tightly controlled signalling cascades, many of which are dependent upon intracellular calcium (Ca(2+)). Despite this, most work investigating calcium signalling in memory formation has focused on plasma membrane channels and extracellular sources of Ca(2+). The intracellular Ca(2+) release channels, ryanodine receptors (RyRs) and inositol (1,4,5)-trisphosphate receptors (IP3Rs) have a significant capacity to regulate intracellular Ca(2+) signalling. Evidence at both cellular and behavioural levels implicates both RyRs and IP3Rs in synaptic plasticity and memory formation. Pharmacobehavioural experiments using young chicks trained on a single-trial discrimination avoidance task have been particularly useful by demonstrating that RyRs and IP3Rs have distinct roles in memory formation. RyR-dependent Ca(2+) release appears to aid the consolidation of labile memory into a persistent long-term memory trace. In contrast, IP3Rs are required during long-term memory. This review discusses various functions for RyRs and IP3Rs in memory processing, including neuro- and glio-transmitter release, dendritic spine remodelling, facilitating vasodilation, and the regulation of gene transcription and dendritic excitability. Altered Ca(2+) release from intracellular stores also has significant implications for neurodegenerative conditions.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Señalización del Calcio
/
Memoria
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Plasticidad Neuronal
Límite:
Animals
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Humans
Idioma:
En
Revista:
Neurosci Biobehav Rev
Año:
2013
Tipo del documento:
Article
País de afiliación:
Australia