Photoreactivation of cyclobutane dimers and (6-4) photoproducts in the epidermis of the marsupial, Monodelphis domestica.
Photochem Photobiol
; 51(6): 653-8, 1990 Jun.
Article
en En
| MEDLINE
| ID: mdl-2367561
ABSTRACT
Radioimmunoassays were used to investigate the repair of cyclobutane pyrimidine dimers and pyrimidine (6-4)pyrimidone photoproducts ((6-4] photoproducts) in the epidermis of the South American opossum, Monodelphis domestica. In the absence of photoreactivating light, both types of photodamage were excised with similar kinetics, 50% of the damage remaining 8 h after UV irradiation in vivo. Exposure of UV-irradiated skin to photoreactivating light resulted in removal of most of the cyclobutane dimers and an enhanced rate of (6-4) photoproduct repair. Photoenhanced excision repair of non-dimer damage increases the range of biologically effective lesions removed by in vivo photoreactivation.
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Bases de datos:
MEDLINE
Asunto principal:
Dímeros de Pirimidina
/
Piel
/
Rayos Ultravioleta
/
Daño del ADN
Límite:
Animals
Idioma:
En
Revista:
Photochem Photobiol
Año:
1990
Tipo del documento:
Article