Targeting self-renewal pathways in myeloid malignancies.
Cell Commun Signal
; 11(1): 33, 2013 May 15.
Article
en En
| MEDLINE
| ID: mdl-23675967
ABSTRACT
A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through transcriptional networks. Key activators/regulators of self-renewal include chemokines, cytokines and morphogens which are expressed in the bone marrow niche, either in a paracrine or autocrine fashion, and modulate stem cell behaviour. Increasing evidence suggests that the downstream signaling pathways induced by these ligands converge at multiple levels providing a degree of redundancy in steady state hematopoiesis. Here we will focus on how these pathways cross-talk to regulate HSC self-renewal highlighting potential therapeutic windows which could be targeted to prevent leukemic stem cell self-renewal in myeloid malignancies.
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Bases de datos:
MEDLINE
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En
Revista:
Cell Commun Signal
Año:
2013
Tipo del documento:
Article
País de afiliación:
Reino Unido