A 4-gene panel as a marker at chromosome 8q in Asian gastric cancer patients.
Genomics
; 102(4): 323-30, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-23722107
ABSTRACT
A widely held viewpoint is that the use of multiple markers, combined in some type of algorithm, will be necessary to provide high enough discrimination between diseased cases and non-diseased. We applied stepwise logistic regression analysis to identify the best combination of the 32 biomarkers at chromosome 8q on an independent public microarray test set of 80 paired gastric samples. A combination of SULF1, INTS8, ATP6V1C1, and GPR172A was identified with a prediction accuracy of 98.0% for discriminating carcinomas from adjacent noncancerous tissues in our previous 25 paired samples. Interestingly, the overexpression of SULF1 was associated with tumor invasion and metastasis. Function prediction analysis revealed that the 4-marker panel was mainly associated with acidification of intracellular compartments. Taken together, we found a 4-gene panel that accurately discriminated gastric carcinomas from adjacent noncancerous tissues and these results had potential clinical significance in the early diagnosis and targeted treatment of gastric cancer.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
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Cromosomas Humanos Par 8
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Sulfotransferasas
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Biomarcadores de Tumor
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Proteínas de la Matriz Extracelular
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ATPasas de Translocación de Protón Vacuolares
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Receptores Acoplados a Proteínas G
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Pueblo Asiatico
Tipo de estudio:
Diagnostic_studies
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Prognostic_studies
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Screening_studies
Límite:
Humans
Idioma:
En
Revista:
Genomics
Asunto de la revista:
GENETICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
China