Efficacy and toxicity of intensity-modulated radiation therapy for prostate cancer in Chinese patients.
Hong Kong Med J
; 19(5): 407-15, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-23784530
ABSTRACT
OBJECTIVE:
To report the treatment efficacy and toxicity profile of intensitymodulated radiation therapy in Chinese patients with clinically localised prostate cancer.DESIGN:
Historical cohort study.SETTING:
Oncology unit in a university teaching hospital in Hong Kong. PATIENTS Patients with clinically localised prostate cancer undergoing intensity-modulated radiation therapy in our institution between May 2001 and November 2009 were reviewed. MAIN OUTCOMEMEASURES:
The 5-year biochemical failurefree survival, 5-year overall survival, as well as acute/late gastro-intestinal toxicities and genito-urinary toxicities.RESULTS:
A total of 182 patients were treated with prostate intensitymodulated radiation therapy with or without whole-pelvic radiotherapy. The median follow-up was 44 months. The median patient age was 72 years. Overall survival of the cohort was 92% after 5 years. The favourable, intermediate, and unfavourable risk category distributions of the National Comprehensive Cancer Network were 21 (12%), 42 (23%), and 119 (65%), respectively. The 5-year actuarial biochemical failurefree survival rates for patients in these categories were 95%, 82%, and 80%, respectively. Multivariate analysis identified early tumour stage, low pre-treatment prostate-specific antigen levels, and the use of adjuvant androgen deprivation as independent prognostic factors for better biochemical failurefree survival. Grade 2 and 3 late gastro-intestinal/genito-urinary toxicities occurred in 8%/3% and 4%/3% of the patients, respectively.CONCLUSION:
Intensity-modulated radiation therapy for prostate cancer is feasible and safe in the Chinese population. These data are consistent with the results of other series in Caucasian populations.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
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Antígeno Prostático Específico
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Radioterapia de Intensidad Modulada
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Aged80
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Humans
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Male
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Hong Kong Med J
Asunto de la revista:
MEDICINA
Año:
2013
Tipo del documento:
Article