Correlation of contrast-enhanced ultrasound kinetics with prognostic factors in invasive breast cancer.
Eur Radiol
; 23(12): 3228-36, 2013 Dec.
Article
en En
| MEDLINE
| ID: mdl-23821023
ABSTRACT
OBJECTIVES:
To correlate contrast-enhanced ultrasound (CEUS) kinetic parameters with traditional and molecular prognostic factors in invasive breast cancer.METHODS:
Seventy-five invasive breast cancers were evaluated with contrast harmonic imaging after the injection of a bolus dose of 2.4 ml sulphur hexafluoride microbubble contrast agent. The lognormal function was used for quantitative analysis of kinetic data. These parameters correlated with traditional prognostic factors (tumour size, histological type, tumour grade, axillary lymph node status) and immunohistochemical biomarkers (ER, PR and HER2 status).RESULTS:
Statistically significant correlation was found between time-to-peak and tumour grade (P value = 0.023), PR status (P value = 0.042) and axillary node status (P value = 0.025). Wash-out ratio, measured at 21 s was significantly associated with ER status (P value = 0.042) and PR status (P value = 0.026).CONCLUSIONS:
Invasive breast carcinomas exhibiting earlier peak enhancement and faster elimination of microbubble contrast agent at CEUS are found to be associated with established predictors of poor prognosis.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Hexafluoruro de Azufre
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Neoplasias de la Mama
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Aumento de la Imagen
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Carcinoma Papilar
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Adenocarcinoma
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Adenocarcinoma Mucinoso
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Carcinoma Ductal
Tipo de estudio:
Diagnostic_studies
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Evaluation_studies
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Prognostic_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Eur Radiol
Asunto de la revista:
RADIOLOGIA
Año:
2013
Tipo del documento:
Article