Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems.
Org Biomol Chem
; 11(36): 6108-12, 2013 Sep 28.
Article
en En
| MEDLINE
| ID: mdl-23921718
ABSTRACT
Amphiphilic calix[4]arenes were designed as phospholipid mimics by incorporating PO3H2 or NMe3(+) head groups. Using PC12 cells and three stressors (H2O2, menadione and glutamate), we established safe calix[4]arene levels that are able not only to deliver antioxidant payloads of curcumin, but intriguingly also have inherent antioxidant properties. The calix[4]arenes appear to be potent synthetic antioxidants that could be used as nano-carriers for drug delivery.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fenoles
/
Fosfolípidos
/
Sistemas de Liberación de Medicamentos
/
Calixarenos
/
Micelas
/
Antioxidantes
Límite:
Animals
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Australia