Phenanthrenes from Juncus effusus.
Planta Med
; 79(15): 1447-52, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-23979834
ABSTRACT
A chemical investigation of the EtOAc-soluble fraction from the ethanol extract of the medullae of Juncus effusus led to the isolation of three new 9,10-dihydrophenanthrenes, juncuenins E-G (1-3); two new phenanthrenes, dehydrojuncuenins D-E (4-5); one new feruloylated glycoside (6); and one known 9,10-dihydrophenanthrene (7). The structures of these compounds were determined by analyzing their spectroscopic data. Metabolites 1-4 and 7 were further evaluated for their in vitro cytotoxic activities against seven human cancer lines (A549, MCF-7, BEL-7402, HeLa, COLO205, BGC-823, and SK-OV-3). Among them, compound 1 exhibited weak cytotoxicity against MCF-7 and HeLa cell lines. Compound 7 showed moderate cytotoxicity against MCF-7 and HeLa cell lines, with IC50 values of 9.17 and 19.6 µM, respectively.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fenantrenos
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Extractos Vegetales
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Magnoliopsida
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Fitoterapia
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Neoplasias
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Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
Planta Med
Año:
2013
Tipo del documento:
Article
País de afiliación:
China