The toll and Imd pathways are not required for wolbachia-mediated dengue virus interference.
J Virol
; 87(21): 11945-9, 2013 Nov.
Article
en En
| MEDLINE
| ID: mdl-23986574
ABSTRACT
Wolbachia blocks dengue virus replication in Drosophila melanogaster as well as in Aedes aegypti. Using the Drosophila model and mutations in the Toll and Imd pathways, we showed that neither pathway is required for expression of the dengue virus-blocking phenotype in the Drosophila host. This provides additional evidence that the mechanistic basis of Wolbachia-mediated dengue virus blocking in insects is more complex than simple priming of the host insect innate immune system.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Wolbachia
/
Proteínas de Drosophila
/
Virus del Dengue
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Drosophila melanogaster
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Receptores Toll-Like
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Interacciones Microbianas
Límite:
Animals
Idioma:
En
Revista:
J Virol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Australia