Reduction of toxicity by reversing the order of infusion of docetaxel and cyclophosphamide.
Chemotherapy
; 59(2): 93-8, 2013.
Article
en En
| MEDLINE
| ID: mdl-24008436
ABSTRACT
BACKGROUND:
This retrospective study aimed to determine whether adverse events are more common in docetaxel followed by cyclophosphamide (TC) as compared to the reverse infusion order (rTC).METHODS:
A retrospective analysis was undertaken at a single institution for 92 consecutive cases treated with TC or rTC for stage I-III breast cancer in a neoadjuvant/adjuvant setting between December 2006 and June 2011. TC was administered during the first 2.5 years and rTC in the latter 2 years.RESULTS:
Among the 92 cases, 50 were in the TC arm and 42 in the rTC arm. Fatigue (72.0 vs. 23.8%), edema (48.0 vs. 16.7%), peripheral neuropathy (66.0 vs. 14.3%), myalgia (48.0 vs. 9.5%) and stomatitis (48.0 vs. 16.7%) occurred significantly more often in cases receiving TC compared to rTC, respectively.CONCLUSION:
Nonhematological toxicities are less common in cases receiving rTC in comparison to those receiving TC.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Ciclofosfamida
/
Taxoides
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Chemotherapy
Año:
2013
Tipo del documento:
Article
País de afiliación:
Japón