Modulation of prion by small molecules: from monovalent to bivalent and multivalent ligands.
Curr Top Med Chem
; 13(19): 2491-503, 2013.
Article
en En
| MEDLINE
| ID: mdl-24059331
ABSTRACT
Prion diseases are fatal neurodegenerative disorders that affect humans and animals and for which no pharmacological treatment is available. Compounds consisting of two identical moieties joined via an appropriate spacer (i.e. bivalent compounds) have turned out to be effective tools to prevent prion fibril formation and exhibit an improved biological profile with regard to the corresponding monovalent derivatives. In this review we discuss the importance of the bivalent strategy as a viable approach to design new chemical entities to combat prion diseases.
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Bases de datos:
MEDLINE
Asunto principal:
Priones
/
Enfermedades por Prión
/
Bibliotecas de Moléculas Pequeñas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Top Med Chem
Asunto de la revista:
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
España