Cell-mediated cytotoxicity patterns of cloned cytotoxic T lymphocytes. Cytotoxicity directed against canine lymphoblasts, monocytes, and endothelial cells.
Transplantation
; 39(6): 657-60, 1985 Jun.
Article
en En
| MEDLINE
| ID: mdl-2408367
ABSTRACT
Knowledge of the antigens recognized during allograft rejection is still incomplete. Cloned cytotoxic T lymphocytes were used to study the distribution of target determinants in the dog. CTL clones were obtained with a limiting dilution technique from effector cells generated in mixed lymphocyte culture. The clones have been tested for cell-mediated cytotoxicity against PHA-stimulated lymphoblasts, monocytes, and arterial and venous endothelial cells. A limited number of patterns of lysis of one, or more than one, of the four different target cells was observed. The nature of the possible target determinants recognized by these CTL-clones is discussed.
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Bases de datos:
MEDLINE
Asunto principal:
Linfocitos
/
Monocitos
/
Linfocitos T Citotóxicos
/
Citotoxicidad Inmunológica
/
Endotelio
/
Inmunidad Celular
Límite:
Animals
Idioma:
En
Revista:
Transplantation
Año:
1985
Tipo del documento:
Article