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Minute ventilation during spontaneous breathing, high-intensity noninvasive positive pressure ventilation and intelligent volume assured pressure support in hypercapnic COPD.
Ekkernkamp, Emelie; Kabitz, Hans-Joachim; Walker, David J; Schmoor, Claudia; Storre, Jan H; Windisch, Wolfram; Dreher, Michael.
Afiliación
  • Ekkernkamp E; 1Department of Pneumology, Cologne-Merheim Hospital, Kliniken der Stadt Köln gGmbH, Witten/Herdecke University Hospital , Ostmerheimer Strasse 200, D-51109 Cologne , Germany.
COPD ; 11(1): 52-8, 2014 Feb.
Article en En | MEDLINE | ID: mdl-24111578
BACKGROUND: High-intensity noninvasive positive pressure ventilation (HI-NPPV) is an effective treatment option in patients with stable hypercapnic chronic obstructive pulmonary disease (COPD). However, the effect of HI-NPPV compared with spontaneous breathing (SB) on minute ventilation (MV) in patients receiving long-term treatment remains to be determined. This study compared MV during HI-NPPV and SB. In addition, the ability of intelligent volume assured pressure support (iVAPS) to increase MV to the same extent as HI-NPPV was determined. METHODS: Daytime pneumotachographic measurements were performed during SB, HI-NPPV and iVAPS. RESULTS: Twenty-seven stable hypercapnic COPD patients (mean FEV1 34 ± 15% predicted) who had been treated with HI-NPPV for a median of 22 months (interquartile range 8.5-84 months) were enrolled. Mean MV was 9.5 ± 1.7 L/min during SB and 12.1 ± 2.8 L/min during HI-NPPV, an increase of 2.5 L/min (95% CI [1.5-3.6] p < 0.001), or 26%. MV during iVAPS was 11.7 ± 3.6 L/min, an increase of 1.8 L/min (95%CI [0.7-3.0], p = 0.003) compared with SB. There was no difference in MV between HI-NPPV and iVAPS (p = 0.25). CONCLUSION: Long-term HI-NPPV increased MV by an average of 26% compared with SB in stable hypercapnic COPD patients. A similar increase in MV was observed during use of iVAPS.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Respiración / Ventilación Pulmonar / Enfermedad Pulmonar Obstructiva Crónica / Hipercapnia / Pulmón Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Middle aged Idioma: En Revista: COPD Año: 2014 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Respiración / Ventilación Pulmonar / Enfermedad Pulmonar Obstructiva Crónica / Hipercapnia / Pulmón Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Middle aged Idioma: En Revista: COPD Año: 2014 Tipo del documento: Article País de afiliación: Alemania