Autocrine VEGF signaling promotes proliferation of neoplastic Barrett's epithelial cells through a PLC-dependent pathway.

Zhang, Qiuyang; Yu, Chunhua; Peng, Sui; Xu, Hao; Wright, Ellen; Zhang, Xi; Huo, Xiaofang; Cheng, Edaire; Pham, Thai H; Asanuma, Kiyotaka; Hatanpaa, Kimmo J; Rezai, Davood; Wang, David H; Sarode, Venetia; Melton, Shelby; Genta, Robert M; Spechler, Stuart J; Souza, Rhonda F

Zhang, Qiuyang; Yu, Chunhua; Peng, Sui; Xu, Hao; Wright, Ellen; Zhang, Xi; Huo, Xiaofang; Cheng, Edaire; Pham, Thai H; Asanuma, Kiyotaka; Hatanpaa, Kimmo J; Rezai, Davood; Wang, David H; Sarode, Venetia; Melton, Shelby; Genta, Robert M; Spechler, Stuart J; Souza, Rhonda F.

Afiliación

Zhang Q; Center for Esophageal Diseases, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Department of Internal Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas.
Yu C; Center for Esophageal Diseases, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Department of Internal Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas.
Peng S; Center for Esophageal Diseases, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Department of Internal Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Division of Gastroenter
Xu H; Department of Internal Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas.
Wright E; Department of Research and Development, VA North Texas Heath Care System, Dallas, Texas.
Zhang X; Center for Esophageal Diseases, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Department of Internal Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas.
Huo X; Center for Esophageal Diseases, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Department of Internal Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas.
Cheng E; Center for Esophageal Diseases, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Department of Internal Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Department of Pediatric
Pham TH; Center for Esophageal Diseases, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Department of Surgery, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas.
Asanuma K; Center for Esophageal Diseases, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Department of Internal Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas.
Hatanpaa KJ; Department of Pathology, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas.
Rezai D; Center for Esophageal Diseases, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Department of Research and Development, VA North Texas Heath Care System, Dallas, Texas.
Wang DH; Center for Esophageal Diseases, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Department of Internal Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Harold C. Simmons Compr
Sarode V; Department of Pathology, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas.
Melton S; Center for Esophageal Diseases, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Department of Pathology, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas.
Genta RM; Center for Esophageal Diseases, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Department of Pathology, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Miraca Life Sciences, Inc., Irv
Spechler SJ; Center for Esophageal Diseases, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Department of Internal Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Harold C. Simmons Compr
Souza RF; Center for Esophageal Diseases, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Department of Internal Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas; Harold C. Simmons Compr

Gastroenterology ; 146(2): 461-72.e6, 2014 Feb.

Article en En | MEDLINE | ID: mdl-24120473

Asunto(s)

Adenocarcinoma/metabolismo; Esófago de Barrett/metabolismo; Biomarcadores de Tumor/metabolismo; Neoplasias Esofágicas/metabolismo; Lesiones Precancerosas/metabolismo; Factor A de Crecimiento Endotelial Vascular/metabolismo; Receptor 2 de Factores de Crecimiento Endotelial Vascular/metabolismo; Adenocarcinoma/tratamiento farmacológico; Adenocarcinoma/patología; Animales; Antineoplásicos/uso terapéutico; Comunicación Autocrina; Esófago de Barrett/patología; Biomarcadores/metabolismo; Línea Celular; Proliferación Celular; Neoplasias Esofágicas/tratamiento farmacológico; Neoplasias Esofágicas/patología; Femenino; Humanos; Inmunohistoquímica; Indoles/uso terapéutico; Sistema de Señalización de MAP Quinasas/fisiología; Ratones; Fosfolipasa C gamma/metabolismo; Fosforilación; Lesiones Precancerosas/patología; Proteína Quinasa C/metabolismo; Pirroles/uso terapéutico; Reacción en Cadena en Tiempo Real de la Polimerasa; Sunitinib; Resultado del Tratamiento

Palabras clave

Apoptosis; BAR-T; BrdU; ERK; Esophageal Cancer; Mouse Model; PKC; PLC; PLCG1; VEGF; VEGF-NA; VEGFR; Vascular Endothelial Growth Factor Receptor 2; bromodeoxyuridine; extracellular signal-regulated kinase; mRNA; messenger RNA; non-neoplastic, telomerase-immortalized Barrett's epithelial cell; phospholipase C; phospholipase CÎ³1; protein kinase C; recombinant human vascular endothelial growth factor; rhVEGF; shRNA; short-hairpin RNA; siRNA; small interfering RNA; vascular endothelial growth factor; vascular endothelial growth factor neutralization antibody; vascular endothelial growth factor receptor

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Lesiones Precancerosas / Esófago de Barrett / Neoplasias Esofágicas / Adenocarcinoma / Biomarcadores de Tumor / Receptor 2 de Factores de Crecimiento Endotelial Vascular / Factor A de Crecimiento Endotelial Vascular Tipo de estudio: Evaluation_studies / Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Gastroenterology Año: 2014 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google