Lectin of Abelmoschus esculentus (okra) promotes selective antitumor effects in human breast cancer cells.
Biotechnol Lett
; 36(3): 461-9, 2014 Mar.
Article
en En
| MEDLINE
| ID: mdl-24129958
ABSTRACT
The anti-tumor effects of a newly-discovered lectin, isolated from okra, Abelmoschus esculentus (AEL), were investigated in human breast cancer (MCF7) and skin fibroblast (CCD-1059 sk) cells. AEL induced significant cell growth inhibition (63 %) in MCF7 cells. The expression of pro-apoptotic caspase-3, caspase-9, and p21 genes was increased in MCF7 cells treated with AEL, compared to those treated with controls. In addition, AEL treatment increased the Bax/Bcl-2 ratio in MCF7 cells. Flow cytometry also indicated that cell death (72 %) predominantly occurred through apoptosis. Thus, AEL in its native form promotes selective antitumor effects in human breast cancer cells and may represent a potential therapeutic to combat human breast cancer.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Apoptosis
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Abelmoschus
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Células Epiteliales
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Fibroblastos
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Lectinas
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Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Biotechnol Lett
Año:
2014
Tipo del documento:
Article
País de afiliación:
Brasil