Prevalence of dengue virus infection in US travelers who have lived in or traveled to dengue-endemic countries.
J Travel Med
; 20(6): 352-60, 2013.
Article
en En
| MEDLINE
| ID: mdl-24165381
ABSTRACT
BACKGROUND:
Dengue virus (DENV) infections may occur in travelers.OBJECTIVES:
To determine prevalence of anti-DENV IgG antibody in travelers who lived in or visited dengue-endemic countries and to describe risk factors and characteristics associated with infection and subsequent anti-DENV IgG antibody presence.METHODS:
Participants were enrolled from travel clinics of the Boston Area Travel Medicine Network from August 2008 through June 2009. Demographic information, trip duration, travel history, and a blood sample were collected. Serum samples were tested for anti-DENV IgG antibody by indirect IgG enzyme-linked immunosorbent assay (ELISA), and antibody-mediated virus neutralization by plaque reduction neutralization test (PRNT) for anti-DENV IgG antibody-positive and selected negative samples. Participants were stratified into group 1 born in dengue-endemic countries; group 2 born in nonendemic countries but lived continuously for ≥1 year in a dengue-endemic country; group 3 born in nonendemic countries and traveled to a dengue-endemic country for ≥2 weeks but <1 year.RESULTS:
Six hundred travelers were enrolled. Anti-DENV IgG antibody was identified in 113 (19%) when tested by ELISA (51% in group 1, 40% in group 2, and 6.9% in group 3) and in 71 (12%) by PRNT (42% primary monotypic and 58% heterotypic reactive responses). Sensitivity and specificity of the ELISA based on PRNT results were 85% to 100% and 79% to 94%, assuming up to 15% misclassification of ELISA negative results. Presence of anti-DENV IgG antibody by ELISA was associated with years lived in dengue-endemic countries and birthplace in the Caribbean for group 1, receipt of Japanese encephalitis vaccine in group 3, and self-reported history of dengue in all three groups.CONCLUSIONS:
Nineteen percent of participants who were born, lived in, or traveled to dengue-endemic countries had anti-DENV IgG antibody by ELISA; 12% had antibodies by PRNT, 85% of whom had no history of dengue. Presence of DENV antibodies was associated with years lived in dengue-endemic countries and self-reported history of dengue.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Viaje
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Inmunoglobulina G
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Enfermedades Endémicas
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Dengue
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Virus del Dengue
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Anticuerpos Antivirales
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Travel Med
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
/
SAUDE PUBLICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos